Targeting Complement to Overcome Real World Safety Challenges to AAVs
Time: 4:30 pm
day: Day Two
Details:
- Examine the role of complement in mediating immune responses to AAV vectors is nuanced
- The classical view of complement-mediated toxicity in the context of high AAVs doses and existing nAbs is probably too limited and has led to the emergence of unexpected safety issues in humans
- The animal models are limited in their ability to predict immunotoxicity to AAV in humans, particularly when the complement system is broadly involved
