Targeting Complement to Overcome Real World Safety Challenges to AAVs

Time: 4:30 pm
day: Day Two

Details:

  • Examine the role of complement in mediating immune responses to AAV vectors is nuanced
  • The classical view of complement-mediated toxicity in the context of high AAVs doses and existing nAbs is probably too limited and has led to the emergence of unexpected safety issues in humans
  •  The animal models are limited in their ability to predict immunotoxicity to AAV in humans, particularly when the complement system is broadly involved

Speakers: