Limitations of Current Animal Models to Predict the Immune Response to AAV Vectors
Time: 8:45 am
day: Day One
- Understand the importance of considering species specific differences such as, the tropism of AAV capsid and natural infection with wild-type AAVs for meaningful translation in humans
- Can we bridge the gap of innate immune responses (PRRs and complement) to AAV vectors in animal models and humans?
- Uncover the benefits and limitations of a humanized versus a multiple animal model approach to study adaptive immune responses to the AAV capsid and transgene product